Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches

Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches

Acute myeloid leukemia (AML), the most common acute leukemia in the adult, is believed to arise as a consequence of multiple molecular events that confer on primitive hematopoietic progenitors unlimited self-renewal potential and cause defective differentiation. A number of genetic aberrations, amon...

Full description

Bibliographic Details
Main Authors: Maria Mesuraca, Nicola Amodio, Emanuela Chiarella, Stefania Scicchitano, Annamaria Aloisio, Bruna Codispoti, Valeria Lucchino, Ylenia Montalcini, Heather M. Bond, Giovanni Morrone
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
acute myeloid leukemia
chromosomal translocations
genetic aberrations
genome editing
leukemia stem cells
viral vectors
xenotransplants
Online Access:http://www.mdpi.com/1420-3049/23/8/2060

Internet

http://www.mdpi.com/1420-3049/23/8/2060

Similar Items