Addressing uncertainty in genome-scale metabolic model reconstruction and analysis

Abstract The reconstruction and analysis of genome-scale metabolic models constitutes a powerful systems biology approach, with applications ranging from basic understanding of genotype-phenotype mapping to solving biomedical and environmental problems. However, the biological insight obtained from...

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Bibliographic Details
Main Authors: David B. Bernstein, Snorre Sulheim, Eivind Almaas, Daniel Segrè
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-021-02289-z