Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD

Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD

Abstract Background Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline. Defective macrophage phagocytosis in COPD drives inflammation, but how defective macrophage function contributes to exacerbations is n...

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Bibliographic Details
Main Authors: R. Singh, K. B. R. Belchamber, P. S. Fenwick, K. Chana, G. Donaldson, J. A. Wedzicha, P. J. Barnes, L. E. Donnelly, COPDMAP consortium
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Respiratory Research
Subjects:
COPD
Exacerbation
Macrophage
Lower airway bacterial colonisation
Online Access:https://doi.org/10.1186/s12931-021-01718-8

Internet

https://doi.org/10.1186/s12931-021-01718-8

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