Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction
IgE is linked to allergic diseases and there is a great interest in developing anti-IgE therapeutics. Here the authors characterize the binding of human IgE Fc to a single domain antibody (sdab) and show that the sdab induces a closed conformation, which prevents and disrupts IgE binding to its rece...
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Bibliographic Details
| Main Authors: |
Frederic Jabs,
Melanie Plum,
Nick S. Laursen,
Rasmus K. Jensen,
Brian Mølgaard,
Michaela Miehe,
Marco Mandolesi,
Michèle M. Rauber,
Wolfgang Pfützner,
Thilo Jakob,
Christian Möbs,
Gregers R. Andersen,
Edzard Spillner |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02312-7
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