Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

Clinical and animal model studies have implicated inflammation and peripheral immune cell responses in the pathophysiology of Alzheimer's disease (AD). Peripheral immune cells including T cells circulate in the cerebrospinal fluid (CSF) of healthy adults and are found in the brains of AD patien...

Full description

Bibliographic Details
Main Authors: Kathryn P. MacPherson, Pradoldej Sompol, George T. Kannarkat, Jianjun Chang, Lindsey Sniffen, Mary E. Wildner, Christopher M. Norris, Malú G. Tansey
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Neurobiology of Disease
Subjects:
Neuroinflammation
Alzheimer's disease
Immune cell trafficking
T cells
Macrophage
MHCII
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300396

Internet

http://www.sciencedirect.com/science/article/pii/S0969996117300396

Similar Items