Peroxisome Proliferator-Activated Receptor Gamma Negatively Regulates the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Toward Myofibroblasts in Liver Fibrogenesis

Peroxisome Proliferator-Activated Receptor Gamma Negatively Regulates the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Toward Myofibroblasts in Liver Fibrogenesis

Background/Aims: Bone marrow-derived mesenchymal stem cells (BMSCs) have been confirmed to have capacity to differentiate toward hepatic myofibroblasts, which contribute to fibrogenesis in chronic liver diseases. Peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-activated t...

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Bibliographic Details
Main Authors: Shuangshuang Jia, Xin Liu, Weiyang Li, Jieshi Xie, Le Yang, Liying Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Peroxisome proliferator-activated receptor gamma
Bone marrow-derived mesenchymal stem cells
Differentiation
Fibrogenesis
Transforming growth factor β1
Online Access:http://www.karger.com/Article/FullText/438567

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http://www.karger.com/Article/FullText/438567

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