Recombinant in vitro assembled hepatitis C virus core particles induce strong specific immunity enhanced by formulation with an oil-based adjuvant

Recombinant in vitro assembled hepatitis C virus core particles induce strong specific immunity enhanced by formulation with an oil-based adjuvant

In the present work, immunogenicity of recombinant in vitro assembled hepatitis C virus core particles, HCcAg.120-VLPs, either alone or in combination with different adjuvants was evaluated in BALB/c mice. HCcAg.120-VLPs induced high titers of anti-HCcAg.120 antibodies and virus-specific cellular im...

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Bibliographic Details
Main Authors: NELSON ACOSTA-RIVERO, JOANNA POUTOU, LIZ ÁLVAREZ-LAJONCHERE, IVIS GUERRA, YARAIMA AGUILERA, ALEXIS MUSACCHIO, ARMANDO RODRÍGUEZ, JULIO C AGUILAR, VIVIANA FALCON, JULIO C ÁLVAREZ-OBREGON, YORDANKA SORIA, DINORAH TORRES, MARBELIS LINARES, ÁNGEL PÉREZ, JUAN MORALES-GRILLO, SANTIAGO DUEÑAS -CARRERA
Format: Article
Language:English
Published: BMC 2009-01-01
Series:Biological Research
Subjects:
challenge
HCV
immunity
adjuvant
capsid
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100005

Internet

http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100005

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