Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice

Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice

Background and aims: Atherosclerosis is an important cause of clinical cardiovascular events. Atherosclerotic plaques are hypoxic, and reoxygenation improves plaque phenotype. Central players in hypoxia are hypoxia inducible factors (HIF) and their regulators, HIF-prolyl hydroxylase (PHD) isoforms 1...

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Bibliographic Details
Main Authors: Jasper A. F. Demandt, Kim van Kuijk, Thomas L. Theelen, Elke Marsch, Sean P. Heffron, Edward A. Fisher, Peter Carmeliet, Erik A. L. Biessen, Judith C. Sluimer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
atherosclerosis
triglycerides
prolyl hydroxylase domain protein
hematocrit
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.664258/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.664258/full

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