Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

In this study, we performed a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen in mice to identify novel genes or alleles that regulate erythropoiesis. Here, we describe a recessive mouse strain, called RBC19, harbouring a point mutation within the housekeeping gene, Tpi1, which encodes th...

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Bibliographic Details
Main Authors: Ashlee J. Conway, Fiona C. Brown, Elinor J. Hortle, Gaetan Burgio, Simon J. Foote, Craig J. Morton, Stephen M. Jane, David J. Curtis
Format: Article
Language:English
Published: The Company of Biologists 2018-05-01
Series:Disease Models & Mechanisms
Subjects:
Erythropoiesis
N-ethyl-N-nitrosourea
Anaemia
TPI deficiency
Transplantation
Online Access:http://dmm.biologists.org/content/11/5/dmm034678

Internet

http://dmm.biologists.org/content/11/5/dmm034678

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