Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

During cell locomotion and endocytosis, membrane-tethered WASP proteins stimulate actin filament nucleation by the Arp2/3 complex. This process generates highly branched arrays of filaments that grow toward the membrane to which they are tethered, a conflict that seemingly would restrict filament gr...

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Bibliographic Details
Main Authors: Benjamin A Smith, Shae B Padrick, Lynda K Doolittle, Karen Daugherty-Clarke, Ivan R Corrêa Jr, Ming-Qun Xu, Bruce L Goode, Michael K Rosen, Jeff Gelles
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-09-01
Series:eLife
Subjects:
TIRF
WH2
nucleation
Wiskott-Aldrich syndrome protein
verprolin homology
activation
Online Access:https://elifesciences.org/articles/01008

Internet

https://elifesciences.org/articles/01008

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