Abnormal Ca2+ homeostasis, atrial arrhythmogenesis and sinus node dysfunction in murine hearts modelling RyR2 modification

Abnormal Ca2+ homeostasis, atrial arrhythmogenesis and sinus node dysfunction in murine hearts modelling RyR2 modification

RyR2 mutations are implicated in catecholaminergic polymorphic ventricular tachycardia thought to result from altered myocyte Ca2+ homeostasis reflecting inappropriate ‘leakiness’ of RyR2-Ca2+ release channels arising from increases in their basal activity, alterations in their phosphorylation, or d...

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Bibliographic Details
Main Authors: Yanmin eZhang, Gareth David Kingsley Matthews, Ming eLei, Christopher L.-H. Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Physiology
Subjects:
Mutation
sinus node dysfunction
mouse models
atrial arrhythmias
RyR2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00150/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00150/full

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