Bacterial Virus Lambda Gpd-Fusions to Cathelicidins, α- and β-Defensins, and Disease-Specific Epitopes Evaluated for Antimicrobial Toxicity and Ability to Support Phage Display

Bacterial Virus Lambda Gpd-Fusions to Cathelicidins, α- and β-Defensins, and Disease-Specific Epitopes Evaluated for Antimicrobial Toxicity and Ability to Support Phage Display

We showed that antimicrobial polypeptides, when translated as gene fusions to the bacteriophage lambda capsid decoration protein gpD, formed highly toxic molecules within <i>E. coli</i>, suggesting that they can retain their antimicrobial activity conformation when fused to gpD. These in...

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Bibliographic Details
Main Author: Sidney Hayes
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Viruses
Subjects:
bacterial virus
bacteriophage (phage) lambda
gpD gene-fusion
capsid display
human α-defensins
HNP1
HD5
human β-defensins
HBD3
DEFB126
cathelicidins
human LL37
porcine PR39
capsid display density
single epitope particle vaccines
Online Access:https://www.mdpi.com/1999-4915/11/9/869

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https://www.mdpi.com/1999-4915/11/9/869

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