Deletion of Dock10 in B Cells Results in Normal Development but a Mild Deficiency upon In Vivo and In Vitro Stimulations

Deletion of Dock10 in B Cells Results in Normal Development but a Mild Deficiency upon In Vivo and In Vitro Stimulations

We sought to identify genes necessary to induce cytoskeletal change in B cells. Using gene expression microarray, we compared B cells stimulated with interleukin-4 (IL-4) and anti-CD40 antibodies that induce B cell spreading, cell motility, tight aggregates, and extensive microvilli with B cells sti...

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Bibliographic Details
Main Authors: Eva Severinson, Lisa S. Westerberg, Natalija Gerasimčik, Minghui He, Marisa A. P. Baptista
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
B cells
Dock10
cytoskeleton
gene expression
humoral immune response
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00491/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00491/full

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