Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2 and TcJAMYC4

Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2 and TcJAMYC4

Taxus cell suspension culture is a sustainable technology for the industrial production of paclitaxel (Taxol®), a highly modified diterpene anti-cancer agent. The methyl jasmonate (MJ)-mediated paclitaxel biosynthetic pathway is not fully characterized, making metabolic engineering efforts difficult...

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Bibliographic Details
Main Authors: Sangram Keshari Lenka, N. Ezekiel Nims, Kham eVongpaseuth, Rosemary A. Boshar, Susan C Roberts, Elsbeth L Walker
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Plant Science
Subjects:
Paclitaxel
Methyl Jasmonate
MYC2
E-box
Taxus cuspidata
JA-MYC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00115/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00115/full

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