MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.

Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated and hence controls neurogenesis and brain size remains elusive. Here, we demons...

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Bibliographic Details
Main Authors: Dan Xu, Minghui Yao, Yaqing Wang, Ling Yuan, Joerg D Hoeck, Jingwen Yu, Liang Liu, Yvonne Y C Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Dominic C H Ng, Xiaoyin Niu, Bing Su, Axel Behrens, Zhiheng Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2006613

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https://doi.org/10.1371/journal.pbio.2006613

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