Hierarchical Micro-Nano Topography Promotes Cell Adhesion and Osteogenic Differentiation via Integrin α2-PI3K-AKT Signaling Axis

Hierarchical Micro-Nano Topography Promotes Cell Adhesion and Osteogenic Differentiation via Integrin α2-PI3K-AKT Signaling Axis

Surface topography dictates important aspects of cell biological behaviors. In our study, hierarchical micro-nano topography (SLM-AHT) with micro-scale grooves and nano-scale pores was fabricated and compared with smooth topography (S) and irregular micro-scale topography (SLA) surfaces to investiga...

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Bibliographic Details
Main Authors: Huimin Zheng, Yujuan Tian, Qian Gao, Yingjie Yu, Xianyou Xia, Zhipeng Feng, Feng Dong, Xudong Wu, Lei Sui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
topography
adhesion
osteogenic differentiation
integrin α2
PI3K-AKT
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00463/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00463/full

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