Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

We previously developed integrase-defective lentiviral vectors (IDLVs) as an antigen delivery system for inducing strong and prolonged immunity in animal models. Here, we examined the association between persistence of antigen expression and durability of immune response. Following a single intramus...

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Bibliographic Details
Main Authors: Yi-Yu Lin, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, Donatella Negri
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
vaccine
intramuscular immunization
integrase defective lentiviral vectors
muscle
myoblasts
myocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300383

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http://www.sciencedirect.com/science/article/pii/S2329050120300383

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