Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation is emerging as a promising strategy to ameliorate imbalances in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. The small molecule N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide (147) w...

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Bibliographic Details
Main Authors: Ryan Paxman, Lars Plate, Erik A Blackwood, Chris Glembotski, Evan T Powers, R Luke Wiseman, Jeffery W Kelly
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
quinone methide
reactive cysteine
cytochrome p450
protein disulfide isomerase
proteostasis
proteostasis regulator
Online Access:https://elifesciences.org/articles/37168

Internet

https://elifesciences.org/articles/37168

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