Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

Insulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been est...

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Bibliographic Details
Main Authors: Paula I. Moreira, Gemma Casadesus, Mark A. Smith, George Perry, Hyoung-Gon Lee, Cristina Carvalho, Xiongwei Zhu, Sonia Correia, Susana Cardoso, Renato Santos
Format: Article
Language:English
Published: MDPI AG 2009-12-01
Series:Pharmaceuticals
Subjects:
Alzheimer’s disease
amyotrophic lateral sclerosis
Huntington’s disease
insulin
mitochondria
neurodegeneration
Parkinson’s disease
PPARs agonists
Online Access:http://www.mdpi.com/1424-8247/2/3/250/

Internet

http://www.mdpi.com/1424-8247/2/3/250/

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