Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6
The origin recognition complex (ORC) is essential for loading the Mcm2–7 replicative helicase onto DNA during DNA replication initiation. Here, the authors describe several cryo-electron microscopy structures of Drosophila ORC bound to DNA and its cofactor Cdc6 and also report an in vitro reconstitu...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-18067-7 |