A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus.

A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression has been demonstrated in patients with autoim...

Full description

Bibliographic Details
Main Authors: Xiaobing Luo, Wanling Yang, Dong-Qing Ye, Huijuan Cui, Yan Zhang, Nattiya Hirankarn, Xiaoxia Qian, Yuanjia Tang, Yu Lung Lau, Niek de Vries, Paul Peter Tak, Betty P Tsao, Nan Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3128113?pdf=render

Internet

http://europepmc.org/articles/PMC3128113?pdf=render

Similar Items