The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling.

The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling.

The host innate immune response to viral infections often involves the activation of parallel pattern recognition receptor (PRR) pathways that converge on the induction of type I interferons (IFNs). Several viruses have evolved sophisticated mechanisms to attenuate antiviral host signaling by direct...

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Bibliographic Details
Main Authors: Amitava Mukherjee, Stefanie A Morosky, Elizabeth Delorme-Axford, Naomi Dybdahl-Sissoko, M Steven Oberste, Tianyi Wang, Carolyn B Coyne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21436888/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21436888/pdf/?tool=EBI

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