Modified DNA Aptamers for C-Reactive Protein and Lactate Dehydrogenase-5 with Sub-Nanomolar Affinities

Modified DNA Aptamers for C-Reactive Protein and Lactate Dehydrogenase-5 with Sub-Nanomolar Affinities

Human C-reactive protein (CRP) and lactate dehydrogenase are important markers in clinical laboratory testing—the former is used to detect in vivo inflammation, and the latter is used to detect cell necrosis and tissue destruction. We developed aptamers that bind to human CRP and human lactate dehyd...

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Bibliographic Details
Main Authors: Hirotaka Minagawa, Yuka Kataoka, Hiroto Fujita, Masayasu Kuwahara, Katsunori Horii, Ikuo Shiratori, Iwao Waga
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
C-reactive protein
lactate dehydrogenase
aptamer
base-appended base modification
Online Access:https://www.mdpi.com/1422-0067/21/8/2683

Internet

https://www.mdpi.com/1422-0067/21/8/2683

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