Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4

Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4

Abstract Background The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch repair-deficient tumors having high mutation burden. However, this observation does not exclude the existence of neoantigen-specific...

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Main Authors: Jitske van den Bulk, Els M. E. Verdegaal, Dina Ruano, Marieke E. Ijsselsteijn, Marten Visser, Ruud van der Breggen, Thomas Duhen, Manon van der Ploeg, Natasja L. de Vries, Jan Oosting, Koen C. M. J. Peeters, Andrew D. Weinberg, Arantza Farina-Sarasqueta, Sjoerd H. van der Burg, Noel F. C. C. de Miranda
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Genome Medicine
Subjects:
Mismatch repair-proficient (MMR-p)
Tumor-infiltrating lymphocytes
Transforming growth factor-beta
Cancer immunotherapy
Adoptive T cell transfer (ACT)
Low mutation burden
Online Access:https://doi.org/10.1186/s13073-019-0697-8

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https://doi.org/10.1186/s13073-019-0697-8

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