CDH6‐activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers

CDH6‐activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers

Cadherin 6 (CDH6) is significantly overexpressed in advanced ovarian and renal cancers. However, the role of CDH6 in cancer metastasis is largely unclear. Here, we investigated the impact of CDH6 expression on integrin‐mediated metastatic progression. CDH6 preferentially bound to αIIbβ3 integrin, a...

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Bibliographic Details
Main Authors: Rubén A. Bartolomé, Javier Robles, Ángela Martin‐Regalado, Laura Pintado‐Berninches, Miranda Burdiel, Marta Jaén, Carmen Aizpurúa, Juan I. Imbaud, José Ignacio Casal
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Molecular Oncology
Subjects:
CDH6
αIIbβ3 integrin
α2β1 integrin
ovarian and renal cancer
metastasis
platelets
Online Access:https://doi.org/10.1002/1878-0261.12947

Internet

https://doi.org/10.1002/1878-0261.12947

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