Spatial progression and molecular heterogeneity of IDH-mutant glioblastoma determined by DNA methylation-based mapping

Spatial progression and molecular heterogeneity of IDH-mutant glioblastoma determined by DNA methylation-based mapping

Abstract Glioblastoma (GBM) is the most common malignant primary central nervous system (CNS) neoplasm in adults, and has an almost universally poor prognosis. Recently, an emphasis on genetic and epigenetic profiling has revealed a number of molecular features useful in the diagnostic and prognosti...

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Bibliographic Details
Main Authors: James F. Lyon, Varshini Vasudevaraja, Kanish Mirchia, Jamie M. Walker, Robert J. Corona, Lawrence S. Chin, Ivy Tran, Matija Snuderl, Timothy E. Richardson, Mariano S. Viapiano
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Acta Neuropathologica Communications
Subjects:
Astrocytoma
Glioblastoma
DNA methylation profiling
Copy number profiling
IDH-mutation
MGMT methylation
Online Access:https://doi.org/10.1186/s40478-021-01221-7

Internet

https://doi.org/10.1186/s40478-021-01221-7

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