Synthesis and Pharmacological Screening of Several Aroyl and Heteroaroyl Selenylacetic Acid Derivatives as Cytotoxic and Antiproliferative Agents

Synthesis and Pharmacological Screening of Several Aroyl and Heteroaroyl Selenylacetic Acid Derivatives as Cytotoxic and Antiproliferative Agents

The synthesis and cytotoxic activity of a series of twenty six aroyl and heteroaroyl selenylacetic acid derivatives of general formula Ar-CO-Se-CH2-COOH or Heterar-CO-Se-CH2-COOH are reported. The synthesis was carried out by reaction of acyl chlorides with sodium hydrogen selenide, prepared in situ...

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Bibliographic Details
Main Authors: Carmen Sanmartín, Daniel Plano, Enrique Domínguez, María Font, Alfonso Calvo, Celia Prior, Ignacio Encío, Juan Antonio Palop
Format: Article
Language:English
Published: MDPI AG 2009-09-01
Series:Molecules
Subjects:
selenylacetic acid
cytotoxicity
apoptosis
Online Access:http://www.mdpi.com/1420-3049/14/9/3313/

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http://www.mdpi.com/1420-3049/14/9/3313/

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