Metronomic Four-Drug Regimen Has Anti-tumor Activity in Pediatric Low-Grade Glioma; The Results of a Phase II Clinical Trial

Metronomic Four-Drug Regimen Has Anti-tumor Activity in Pediatric Low-Grade Glioma; The Results of a Phase II Clinical Trial

Background: Metronomic chemotherapy (MC) is defined as the frequent administration of chemotherapy at doses below the maximal tolerated dose and with no prolonged drug-free break. MC has shown its efficacy in adult tumor types such as breast and ovarian cancer and has to some extent been studied in...

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Main Authors: Arnauld Verschuur, Marie-Amélie Heng-Maillard, Philippe Dory-Lautrec, Romain Truillet, Elisabeth Jouve, Pascal Chastagner, Pierre Leblond, Isabelle Aerts, Stéphane Honoré, Natasha Entz-Werle, Nicolas Sirvent, Jean-Claude Gentet, Nadège Corradini, Nicolas André
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
metronomic chemotherapy
pediatric oncology
angiogenesis
low grade glioma
immunity
drug repositioning
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00950/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00950/full

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