Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy

Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy

Abstract Background Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration disease (LDD) with typical symptoms of low back pain and limb numbness owing to an abnormal pressure on spinal nerves. Previous studies revealed HLF might be caused by fibrosis, inflammatory, and other bio-pat...

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Bibliographic Details
Main Authors: Yanlin Cao, Yenan Zhan, Sujun Qiu, Zhong Chen, Kaiqin Gong, Songjia Ni, Yang Duan
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Arthritis Research & Therapy
Subjects:
Genome-wide DNA methylation
Single-nucleotide polymorphism
Hypertrophy of ligamentum flavum
ACSM5
Cell fibrosis
Online Access:https://doi.org/10.1186/s13075-021-02625-5

Internet

https://doi.org/10.1186/s13075-021-02625-5

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