Impact of Endotoxins in Gelatine Hydrogels on Chondrogenic Differentiation and Inflammatory Cytokine Secretion In Vitro

Impact of Endotoxins in Gelatine Hydrogels on Chondrogenic Differentiation and Inflammatory Cytokine Secretion In Vitro

Gelatine methacryloyl (GelMA) hydrogels are widely used in studies aimed at cartilage regeneration. However, the endotoxin content of commercially available GelMAs and gelatines used in these studies is often overlooked, even though endotoxins may influence several cellular functions. Moreover, regu...

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Bibliographic Details
Main Authors: Wilhelmina M. G. A. C. Groen, Lizette Utomo, Miguel Castilho, Debby Gawlitta, Jos Malda, P. René van Weeren, Riccardo Levato, Nicoline M. Korthagen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Gelatine Methacryloyl (GelMA)
mesenchymal stromal cell (MSC)
articular cartilage regeneration
peripheral blood mononuclear cell (PBMC)
lipopolysaccharide (LPS)
type A and type B gelatine
Online Access:https://www.mdpi.com/1422-0067/21/22/8571

Internet

https://www.mdpi.com/1422-0067/21/22/8571

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