Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.

Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.

We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter region was met...

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Bibliographic Details
Main Authors: Francesca Lessi, Andrew Beggs, Mariagrazia de Palo, Marcello Anti, Raffaele Macarone Palmieri, Simona Francesconi, Vito Gomes, Generoso Bevilacqua, Ian Tomlinson, Stefania Segditsas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2974649?pdf=render

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http://europepmc.org/articles/PMC2974649?pdf=render

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