Similarities and differences in the biotransformation and transcriptomic responses of Caenorhabditis elegans and Haemonchus contortus to five different benzimidazole drugs

We have undertaken a detailed analysis of the biotransformation of five of the most therapeutically important benzimidazole anthelmintics - albendazole (ABZ), mebendazole (MBZ), thiabendazole (TBZ), oxfendazole (OxBZ) and fenbendazole (FBZ) - in Caenorhabditis elegans and the ruminant parasite Haemo...

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Bibliographic Details
Main Authors: S.J. Stasiuk, G. MacNevin, M.L. Workentine, D. Gray, E. Redman, D. Bartley, A. Morrison, N. Sharma, D. Colwell, D.K. Ro, J.S. Gilleard
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320719300776