Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus paralleled by local microgliosis and microglia activation, which begin at early stages of the disease. However, the possibi...

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Bibliographic Details
Main Authors: Alejandra Bosco, Cesar O. Romero, Kevin T. Breen, Alexis A. Chagovetz, Michael R. Steele, Balamurali K. Ambati, Monica L. Vetter
Format: Article
Language:English
Published: The Company of Biologists 2015-05-01
Series:Disease Models & Mechanisms
Subjects:
Microglia activation
Microgliosis
Retinal ganglion cells
Confocal ophthalmoscopy
Live image analysis
Cx3cr1GFP/+ DBA/2J
Online Access:http://dmm.biologists.org/content/8/5/443

Internet

http://dmm.biologists.org/content/8/5/443

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