Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway

Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway

Pulmonary hypertension (PH) is an extremely serious cardiopulmonary disease, finally leading to progressive right ventricular failure and death. Our previous studies have nominated HLQ2g, a pyrazolo[3,4-b] pyridine derivative stimulating soluble guanylate cyclase (sGC), as a new candidate for the tr...

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Bibliographic Details
Main Authors: Lijun Li, Minghui Yin, Liqing Hu, Xiaoting Tian, Xiangrong He, Congke Zhao, Ying Li, Qianbin Li, Xiaohui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary hypertension
hypoxia
cGKI
BMP signaling pathway
pulmonary artery smooth muscle cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.691405/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.691405/full

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