Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling

Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling

Tubulointerstitial fibrosis (TIF) plays an important role in the progression of renal fibrosis in diabetic nephropathy (DN). Accumulating evidence supports a crucial inhibitory effect of dapagliflozin, a SGLT2 inhibitor, on TIF, but the underlying mechanisms remain largely unknown. This study aimed...

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Bibliographic Details
Main Authors: Fengjuan Huang, Yanyan Zhao, Qingzhu Wang, Jan-Luuk Hillebrands, Jacob van den Born, Linlin Ji, Tingting An, Guijun Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Endocrinology
Subjects:
dapagliflozin
tubulointerstitial fibrosis
epithelial mesenchymal transition
STAT1
TGF-β1
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00441/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00441/full

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