Allosteric Regulation of Hsp90α’s Activity by Small Molecules Targeting the Middle Domain of the Chaperone

Allosteric Regulation of Hsp90α’s Activity by Small Molecules Targeting the Middle Domain of the Chaperone

Summary: Hsp90 is a target for anti-cancer drug development. Both the conformational events tuned by ATP/ADP and co-chaperones and the chaperoning cycle timing are required for Hsp90's fully functional display. Interfering with either one of the conformational events or the cycle timing will do...

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Bibliographic Details
Main Authors: Chen Zhou, Chi Zhang, Hongwen Zhu, Zhijun Liu, Haixia Su, Xianglei Zhang, Tingting Chen, Yan Zhong, Huifang Hu, Muya Xiong, Hu Zhou, Yechun Xu, Ao Zhang, Naixia Zhang
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220300407

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http://www.sciencedirect.com/science/article/pii/S2589004220300407

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