Polymorphism in the Yersinia LcrV Antigen Enables Immune Escape From the Protection Conferred by an LcrV-Secreting Lactococcus Lactis in a Pseudotuberculosis Mouse Model

Polymorphism in the Yersinia LcrV Antigen Enables Immune Escape From the Protection Conferred by an LcrV-Secreting Lactococcus Lactis in a Pseudotuberculosis Mouse Model

Yersinioses caused by Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica are significant concerns in human and veterinary health. The link between virulence and the potent LcrV antigen has prompted the latter's selection as a major component of anti-Yersinia vaccines. Her...

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Bibliographic Details
Main Authors: Catherine Daniel, Amélie Dewitte, Sabine Poiret, Michaël Marceau, Michel Simonet, Laure Marceau, Guillaume Descombes, Denise Boutillier, Nadia Bennaceur, Sébastien Bontemps-Gallo, Nadine Lemaître, Florent Sebbane
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
plague
Yersinia pestis
vaccine
LcrV
immune escape
polymorphism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01830/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01830/full

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