DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer

DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer

Abstract Background Targeting TopoisomeraseII (TopoII) and generate enzyme mediated DNA damage is an effective strategy for treatment of breast cancer. TopoII is known as a validated target for drug discovery and cancer chemotherapy. Methods XWL-1-48, a new orally podophyllotoxin derivative, was des...

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Bibliographic Details
Main Authors: Yajie Wang, Hua Sun, Zhiyan Xiao, Gang Zhang, Dan Zhang, Xiuqi Bao, Fangfang Li, Shaoyu Wu, Yuanchao Gao, Ning Wei
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
TopoisomeraseII
DNA damage
p53
Mdm2
Online Access:http://link.springer.com/article/10.1186/s12964-018-0263-9

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http://link.springer.com/article/10.1186/s12964-018-0263-9

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