Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice

Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice

Cystatin C is a potent cysteine protease inhibitor that plays an important role in various biological processes including cancer, cardiovascular diseases and neurodegenerative diseases. However, the role of CstC in inflammation is still unclear. In this study we demonstrated that cystatin C-deficien...

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Bibliographic Details
Main Authors: Monika Biasizzo, Mojca Trstenjak-Prebanda, Klemen Dolinar, Sergej Pirkmajer, Janja Završnik, Boris Turk, Nataša Kopitar-Jerala
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
Cystatin C
lipopolysaccharide
NLRP3 inflammasome
autophagy
cysteine proteases
interleukin-1 (IL-1)
Online Access:https://www.mdpi.com/2073-4409/10/8/2071

Internet

https://www.mdpi.com/2073-4409/10/8/2071

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