A single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle

Toxoplasma gondii is the causative pathogen for Toxoplasmosis. Bumped kinase inhibitor 1NM-PP1 inhibits the growth of T. gondii by targeting TgCDPK1. However, we recently reported that resistance to 1NM-PP1 can be acquired via a mutation in T. gondii mitogen-activated protein kinase like 1 (TgMAPKL-...

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Bibliographic Details
Main Authors: Tatsuki Sugi, Shin-ichiro Kawazu, Taisuke Horimoto, Kentaro Kato
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
BKI
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320714000402