Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages.

Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for hypoxic induction are not fully characterised. Her...

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Bibliographic Details
Main Authors: Fattah Sotoodehnejadnematalahi, Karl J Staples, Elvina Chrysanthou, Helen Pearson, Loems Ziegler-Heitbrock, Bernard Burke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4461269?pdf=render