HIV-1 Virologic Rebound Due to Coadministration of Divalent Cations and Bictegravir

Abstract A potential drug-drug interaction exists between divalent and trivalent cations (Ca2+, Fe3+, Mg2+, Al3+, Zn2+) and HIV-1 integrase strand transfer inhibitors (INSTIs). There are limited case reports describing the clinical significance of this potential interaction and none to our knowledge...

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Bibliographic Details
Main Authors: Alex E. Rock, Patricia L. DeMarais, Pamala T. Vergara-Rodriguez, Blake E. Max
Format: Article
Language:English
Published: Adis, Springer Healthcare 2020-07-01
Series:Infectious Diseases and Therapy
Subjects:
HIV
Online Access:https://doi.org/10.1007/s40121-020-00307-4