Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments

Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments

The endothelial cytoskeleton is a barrier for leukocyte transendothelial migration (TEM). Mononuclear and polymorphonuclear leukocytes generate gaps of similar micron-scale size when squeezing through inflamed endothelial barriers in vitro and in vivo. To elucidate how leukocytes squeeze through the...

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Bibliographic Details
Main Authors: Sagi Barzilai, Sandeep Kumar Yadav, Steven Morrell, Francesco Roncato, Eugenia Klein, Liat Stoler-Barak, Ofra Golani, Sara W. Feigelson, Assaf Zemel, Sussan Nourshargh, Ronen Alon
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
inflammation
leukocyte trafficking
adhesion
migration
shear flow
vasculature
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317983

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716317983

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