Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis

Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis

Anaphylaxis, the most serious and life-threatening allergic reaction, produces the release of inflammatory mediators by mast cells and basophils. Regulator of calcineurin 1 (Rcan1) is a negative regulator of mast-cell degranulation. The action of mediators leads to vasodilation and an increase in va...

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Bibliographic Details
Main Authors: Constanza Ballesteros-Martinez, Nerea Mendez-Barbero, Alma Montalvo-Yuste, Bettina M. Jensen, Aída Gomez-Cardenosa, Lotte Klitfod, María Garrido-Arandia, Gloria Alvarez-Llamas, Carlos Pastor-Vargas, Fernando Vivanco, Lene Heise Garvey, Javier Cuesta-Herranz, Lars K. Poulsen, Vanesa Esteban
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
anaphylaxis
endothelial cells
vascular permeability
regulator of calcineurin 1
histamine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01323/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01323/full

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