Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis
Anaphylaxis, the most serious and life-threatening allergic reaction, produces the release of inflammatory mediators by mast cells and basophils. Regulator of calcineurin 1 (Rcan1) is a negative regulator of mast-cell degranulation. The action of mediators leads to vasodilation and an increase in va...
Main Authors: | Constanza Ballesteros-Martinez, Nerea Mendez-Barbero, Alma Montalvo-Yuste, Bettina M. Jensen, Aída Gomez-Cardenosa, Lotte Klitfod, María Garrido-Arandia, Gloria Alvarez-Llamas, Carlos Pastor-Vargas, Fernando Vivanco, Lene Heise Garvey, Javier Cuesta-Herranz, Lars K. Poulsen, Vanesa Esteban |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-10-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01323/full |
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