Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

Abstract Background Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited treatment possibilities. Merkel cell tumors display with neuroendocrine features and Merkel cell polyomavirus (MCPyV) infection in the majority (80%) of patients. Although loss of histone H3 lysine 27 t...

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Bibliographic Details
Main Authors: Hemant Gujar, Arjun Mehta, Hong-Tao Li, Yvonne C. Tsai, Xiangning Qiu, Daniel J. Weisenberger, Miriam Galvonas Jasiulionis, Gino K. In, Gangning Liang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Medicine
Subjects:
DNA methylation marker
Epigenetic therapy
Epigenetic driver
MCC
MCPyV
EZHIP
Online Access:https://doi.org/10.1186/s13073-021-00946-3

Internet

https://doi.org/10.1186/s13073-021-00946-3

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