Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown. We compared epigenomic and regulatory features in cerebral...

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Bibliographic Details
Main Authors: Chongyuan Luo, Madeline A. Lancaster, Rosa Castanon, Joseph R. Nery, Juergen A. Knoblich, Joseph R. Ecker
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
DNA methylation
epigenome
organoid
brain development
3D culture
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316722

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http://www.sciencedirect.com/science/article/pii/S2211124716316722

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