Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53

Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53

Mutation in TP53 is a common genetic alteration in human cancers. Certain tumor associated p53 missense mutants acquire gain-of-function (GOF) properties and confer oncogenic phenotypes including enhanced chemoresistance. The colorectal cancers (CRC) harboring mutant p53 are generally aggressive in...

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Bibliographic Details
Main Authors: Arindam Datta, Sanjib Dey, Pijush Das, Sk. Kayum Alam, Susanta Roychoudhury
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Genomics Data
Subjects:
Mutant p53
Gain-of-function
Transcriptome
Colorectal cancer
Floxuridine
Chemoresistance
Online Access:http://www.sciencedirect.com/science/article/pii/S221359601630040X

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http://www.sciencedirect.com/science/article/pii/S221359601630040X

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