Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting

Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting

In order to be effective models to identify biomarkers of chemotherapy response, cancer cell lines require thorough characterization. In this study, we characterised the widely used high grade serous ovarian cancer (HGSOC) cell line NIH-OVCAR3 using bioinformatics, cytotoxicity assays and molecular/...

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Bibliographic Details
Main Authors: Alice Bradbury, Rachel O’Donnell, Yvette Drew, Nicola J. Curtin, Sweta Sharma Saha
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
ovarian cancer
PARP
ATR
platinum
homologous recombination repair
non-homologous end-joining
Online Access:https://www.mdpi.com/2072-6694/12/7/1939

Internet

https://www.mdpi.com/2072-6694/12/7/1939

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