SMAD5 Gene Expression, Rearrangements, Copy Number, Amplification at Fragile Site FRA5C in Human Hepatocellular Carcinoma

SMAD5 Gene Expression, Rearrangements, Copy Number, Amplification at Fragile Site FRA5C in Human Hepatocellular Carcinoma

Signaling by the transforming growth factor (TGF)family members is transduced from the cell surface to the nucleus by the Smad group of intracellular proteins. Because we detected alterations on the long arm of chromosome 5, we examined the status of the SMAD5 gene in human hepatocellular carcinoma...

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Bibliographic Details
Main Authors: Drazen B. Zimonjic, Marian E. Durkin, Catherine L. Keck-Waggoner, Sang-Won Park, Snorri S. Thorgeirsson, Nicholas C. Popescu
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
SMAD5
gene expression
chromosome rearrangements
gene amplification
fragile sites
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800416

Internet

http://www.sciencedirect.com/science/article/pii/S1476558603800416

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